Protein Details: Voltage-gated sodium channel subunit beta-4

Protein ID

ICDB_Pro_1150

Protein Name

Voltage-gated sodium channel subunit beta-4

Gene Name

Scn4b

Organism

Rattus norvegicus (Rat)

Length

228 amino acids

AlphaFoldDB

AF-Q7M730-F1-model_v4.pdb

Function

Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels; but does not affect the voltage dependence of inactivation. Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider; scorpion; wasp and sea anemone venom.

Sequence

MSRAGNRGNTQARWLGIGLLGLFLLPMYLSLEVSVGKATTIYAINGSAILLPCTFSSCYGFENLYFRWSYNNSETSRILIDGIVKNDKSDPKVRVKDDDRITLEGSTKEKMNNISILLSDLEFSDTGRYTCFVRNPKEKDLNNSATIFLQVVDKLEEVDNTVTLIILAVVGGVIGLLVCILLLKKLITFILKKTREKKKECLVSSSGNDNTENGLPGSKAEEKPPTKV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed at a high level in dorsal root ganglia; at a lower level in brain; spinal cord; skeletal muscle and heart

DOI ID

10.1038/nature02426; 10.1523/jneurosci.23-20-07577.2003; 10.1021/pr400783j

RefSeq

NP_001008880.1